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Note that the numbers in parentheses (1, 2, etc.) are clickable links to these studies

These include: Nausea (the most frequently reported adverse effect) Vomiting Diarrhoea Constipation Decreased appetite (which, while contributing to weight loss, can occasionally be excessive) These effects were generally mild to moderate in severity and occurred most frequently during the dose-escalation phase

In 2023, the FDA and European Medicines Agency (EMA) began investigating a possible relationship after receiving reports of suicidal thoughts while patients were taking the drugs